40g/kg. Propylene glycol, 7 PubMed; Horinek EL et al. Propylene glycol is a compound which is GRAS (generally recognized as safe) by the US FDA (Food and Drug Administration) under 21 CFR x184.1666, and is also approved by the FDA for certain uses as an indirect food additive. Propylene Glycols - Density Values Question What are the density values for glycols and glycol-water solutions? It serves as both the carrier for substances like nicotine and cannabinoids, as well as for creating a vapor which resembles smoke.[19]. [9][10] Vaporizers used for delivery of pharmaceuticals or personal-care products often include propylene glycol among the ingredients. It is used as aircraft de-icing fluid. Propylene glycol accumulation in critically ill patients receiving continuous intravenous lorazepam infusions. [38] Cases of propylene glycol poisoning are usually related to either inappropriate intravenous administration or accidental ingestion of large quantities by children. Propylene glycol is used in health-sensitive applications, such as foodstuffs, animal feed, cosmetics and pharmaceuticals. Reproduction of any materials from the site is strictly forbidden without permission. [54] A high percentage (12% to 42%) of directly-injected propylene glycol is eliminated or secreted in urine unaltered depending on dosage, with the remainder appearing in its glucuronide-form. [4][14] Water-propylene glycol mixtures dyed pink to indicate the mixture is relatively nontoxic are sold under the name of RV or marine antifreeze. Product Results, |  Match Criteria: Product Name, Property, Description, Synonym: Propylene glycol methyl ether acetate, .alpha.-isomer / PGMEA / 1-Methoxypropan-2-yl acetate / Acetic acid, 2-methoxyisopropyl ester / 1-Methoxypropan-2-ol acetate 1.2. 4-Methyl-2-phenyl-1,3-dioxolane, Dihydroxyacetone phosphate, one of the two products of breakdown (glycolysis) of fructose 1,6-bisphosphate, is a precursor to methylglyoxal. Empirical Formula (Hill Notation): C10H12O2. Propylene glycol is also present in propylene glycol alginate, which is known as E405. [12] PG is also used as a solvent and carrier for many pharmaceutical capsule preparations. Product Result, Synonym: Propylene glycol methyl ether acetate, 2 Propylene diacetate, Synonym: https://en.wikipedia.org/w/index.php?title=Propylene_glycol&oldid=996339556, Chemical articles with multiple compound IDs, Multiple chemicals in an infobox that need indexing, Chemical articles with multiple CAS registry numbers, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Creative Commons Attribution-ShareAlike License, In veterinary medicine as an oral treatment for. [42], Propylene glycol is essentially non-irritating to the skin. This conversion is the basis of a potential biotechnological route to the commodity chemical 1,2-propanediol. National Library of Medicine;.Propylene glycol is used in antifreezes Human Toxicity Excerpts: CAS Registry Number: 57-55-6 (1,2-Propylene Glycol). matches found for Propylene glycol (IUPAC name: propane-1,2-diol) is a viscous, colorless liquid, which is nearly odorless but possesses a faintly sweet taste. 2005. Always drain and flush systems containing propylene glycol with water before welding or other maintenance. Pricing & availability is not currently available. In this regard, propylene glycol reacts with a mixture of unsaturated maleic anhydride and isophthalic acid to give a copolymer. [56] In one case, intravenous administration of propylene glycol-suspended nitroglycerin to an elderly man may have induced coma and acidosis. [60] Heinz body formation from MPG has not been observed in dogs, cattle, or humans. Propylene glycol, also known as 1,2-propanediol, is a synthetic (i.e., man-made) alcohol that attracts/absorbs water. [39], The potential for long-term oral toxicity is also low. It is a clear, colorelss, viscous liquid, slightly bitter-tasting. *Please select more than one item to compare, 211 Propylene glycol is used by the chemical, food, and pharmaceutical industries as an antifreeze when leakage might lead to contact with food. [26] The safety of electronic cigarettes—which utilize PG-based preparations of nicotine or THC and other cannabinoids—is the subject of much controversy. CAS Number: 2568-25-4. Propylene glycol methyl ether ( PGME or 1-methoxy-2-propanol) is an organic solvent with a wide variety of industrial and commercial uses. "Subchapter B - Food for Human Consumption. Empty containers or liners may retain some product residues. Due to its low toxicity, propylene glycol can be purchased from certain food stores and chemical suppliers, in various grades. In general, glycols are non-irritating and have very low volatility.[4]. Beilstein/REAXYS Number: 1340498. Responses may include CNS depression, "hypotension, bradycardia, QRS and T abnormalities on the ECG, arrhythmia, cardiac arrhythmias, seizures, agitation, serum hyperosmolality, lactic acidosis, and haemolysis". Propylene glycol skin sensitization occurred in patients sensitive to a number of other concomitant positive allergens, most common of which were: Myroxylon pereirae resin, benzalkonium chloride, carba mix, potassium dichromate, neomycin sulfate; for positive propylene glycol reactions, the overall median of 5 and mean of 5.6 concomitant positive allergens was reported. [16][17] The −50 °F/−45 °C commercial product is, however, water rich; a typical formulation is 40:60. [6] Further purification produces finished industrial grade or USP/JP/EP/BP grade propylene glycol that is typically 99.5% or greater. Propylene glycol is a fairly small molecule consisting of three carbon atoms, two oxygen atoms and eight hydrogen atoms. Molecular Weight: 76.09. Because of its potential for allergic reactions and frequent use across a variety of topical and systemic products, propylene glycol was named the American Contact Dermatitis Society's Allergen of the Year for 2018. [43] Undiluted propylene glycol is minimally irritating to the eye, producing slight transient conjunctivitis; the eye recovers after the exposure is removed. The potential hazards of chronic inhalation of propylene glycol or the latter substance as a whole are as-yet unknown. Propylene glycol (IUPAC name: propane-1,2-diol) is a viscous, colorless liquid, which is nearly odorless but possesses a faintly sweet taste. The positive reaction rates were 0%, 0.26%, and 1.86% for 5%, 10%, and 20% propylene glycol respectively, increasing with each concentration increase. Answer Density is the weight per unit volume of a mass. [48][49][50], Propylene glycol has not caused sensitization or carcinogenicity in laboratory animal studies, nor has it demonstrated genotoxic potential.[51][52]. Propylene glycol is frequently used as a substitute for ethylene glycol in low toxicity, environmentally friendly automotive antifreeze. It is miscible with a broad range of solvents, including water, acetone, and chloroform. [15] The eutectic composition/temperature is 60:40 propylene glycol:water/-60 °C. The International Programme on Chemical Safety: Basic Analytical Toxicology. When used in a lotion or ointment, propylene glycol increases the skin’s ability to absorb whatever it’s applied to it, which could help medications work better. Dispose of surplus and non-recyclable products via a In the cosmetics industry, where PG is very commonly used as a carrier or base for various types of makeup. PGMEA, 1,2-Propanediol diacetate, [53] Ruddick (1972) also summarized intramuscular LD50 data for rat as 13-20 mL/kg BW, and 6 mL/kg BW for the rabbit. Related to this application, propylene glycol reacts with propylene oxide to give oligomers and polymers that are used to produce polyurethanes. [4] In alcohol-based hand sanitizers, it is used as a humectant to prevent the skin from drying. Propylene glycol is one of the most widely used cosmetic ingredients, as it is a humectant. Propylene glycol Version 1.2 Revision Date: 10/30/2014 MSDS Number: 100000008803 5 / 16 Propylene glycol Water solubility : completely soluble @ 20 °C (68 °F) Solubility in other sol-vents : No data available Partition coefficient: n-octanol/water : log Pow: -1.07 Auto-ignition temperature : … Wilson KC et al. ", "Material Safety Data Sheet: Winter Care RV Antifreeze", "Predicting Abraham model solvent coefficients", "Atmosphere: Hazers, Fazers, Smoke and Fog 101 by Daniel Brea", "Material Safety Data Sheet Propionaldehyde MSDS", "Database of Select Committee on GRAS Substances (SCOGS) Reviews", "Tests for the chronic toxicity of propylene glycol and triethylene glycol on monkeys and rats by vapor inhalation and oral administration", https://vapingcheap.com/vaping-vs-smoking/#tab-con-1, "Everyday Substances Increase Risk of Allergies in Children, Swedish Study Reveals", "Chemical Compounds Emitted From Common Household Paints and Cleaners Increase Risks of Asthma and Allergies in Children", "Common Household Chemicals and the Allergy Risks in Pre-School Age Children", http://www.inchem.org/documents/pims/chemical/pim443.htm#SectionTitle:9.1%20%20Acute%20poisoning, "Allergen of the year may be nearer than you think", ATSDR - Case Studies in Environmental Medicine: Ethylene Glycol and Propylene Glycol Toxicity. 4-Methyl-2-phenyl-1,3-dioxolane, Synonym: [67] 87% of the reactions were classified as weak and 9% as strong. The LD50 is higher for most laboratory animals (20 mL/kg). Estimated levels of exposure to propylene glycol and glycerine are close enough to [workplace limits] to warrant concern. 57-55-6 1.3 Recommended use of the chemical and restrictions on use Skin Cosmetics 1.4 Supplier's details Name Bulk Apothecary Address 115 Lena Dr Aurora OH 44202 United States Propylene glycol is used by the chemical, food, and pharmaceutical industries as an antifreeze when leakage might lead to Poly(propylene oxide), 4 [4] Propylene glycol is used in waterbased acrylic architectural paints to extend dry time which it accomplishes by preventing the surface from drying due to its slower evaporation rate compared to water. Customer Service. Commercial processes typically use the racemate. Propylene glycol -1 - low 2/10/2010. Product Results, Synonym: [18], Along with vegetable glycerin as the main ingredient (<1–92%) in e-liquid used in electronic cigarettes, where it is aerosolized to resemble smoke. [40] Because of its low chronic oral toxicity, propylene glycol was classified by the U. S. Food and Drug Administration as "generally recognized as safe" (GRAS) for use as a direct food additive, including frozen foods such as ice cream and frozen desserts. It is a colorless, odorless, slightly syrupy liquid that is a bit thicker than water. It also finds use as an industrial and commercial paint stripper. 1,2-Propanediol monomethyl ether acetate, Benzaldehyde propylene glycol acetal, mixture of isomers, Pharmaceutical Secondary Standard; Certified Reference Material, United States Pharmacopeia (USP) Reference Standard, European Pharmacopoeia (EP) Reference Standard, British Pharmacopoeia (BP) Reference Standard. Site Use Terms It is a viscous, colorless liquid, which is … Propylene glycol is a synthetic liquid substance that absorbs water. Propylene glycol is approved and used as a vehicle for topical, oral, and some intravenous pharmaceutical preparations in the U.S. and in Europe. Biopharmaceutical Process Development and Manufacturing, Decanoic acid, mixed diesters with octanoic acid and propylene glycol, Dodecanoic acid, ester with 1,2-propanediol. There are four different propylene glycol. Sorry we cannot compare more than 4 products at a time. CAS Number: 57-55-6. Propylene Glycol USP is the most common moisture-carrying vehicle, other than water itself, in cosmetics. | Privacy. Propylene glycol is an ingredient that acts as a humectant for hair. [11] Propylene glycol is used as a solvent in many pharmaceuticals, including oral, injectable, and topical formulations. [5], Final products contain 20% propylene glycol, 1.5% of dipropylene glycol, and small amounts of other polypropylene glycols. 1999. Although these are great benefits for the hair, some people experience an allergic reaction to propylene glycol on their scalps. 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It is also used to winterize the plumbing systems in vacant structures. [37] It would be nearly impossible to reach toxic levels by consuming foods or supplements, which contain at most 1 g/kg of PG, except for alcoholic beverages in the US which are allowed 5 percent = 50g/kg. Some common applications see PG used: When used in average quantities, propylene glycol has no measurable effect on development and/or reproduction on animals and probably does not adversely affect human development or reproduction. Similarly, the effect concentration determined in marine fish is a 96-h LC50 of >10,000 mg/l in Scophthalmus maximus. The irritant reaction rates were 0.95%, 0.24%, and 0.5% for 5%, 10%, and 20% propylene glycol, respectively. Recommended use and restrictions on use Use of the substance/mixture : Solvent for inks and coatings Use of … [61] Investigators believe that the incidence of allergic contact dermatitis to propylene glycol may be greater than 2% in patients with eczema or fungal infections, which are very common in countries with lesser sun exposure and lower-than-normal vitamin D balances. Many pharmaceutical drugs which are insoluble in water utilize PG as a solvent and carrier; benzodiazepine tablets are one example. Lactic acid and lactaldehyde are common intermediates. U.S. Food and Drug Administration (FDA). The hydroxyl groups are attached to the first and the second carbon atoms. It is degraded by vitamin B12-dependent enzymes, which convert it to propionaldehyde.[68]. Linear Formula: CH 3 CH (OH)CH 2 OH. Decanoic acid, mixed diesters with octanoic acid and propylene glycol, Empirical Formula (Hill Notation): C21H40O4, 3 2 June 2010, FDA. Depending on the molecular weight, poly (propylene) fumarate is a viscous liquid. Containing two alcohol groups, it is classed as a diol. Product Results, Linear Formula: CH3CH(NH2)CH2[OCH2CH(CH3)]nNH2, Linear Formula: H2C=CHCO(OC3H6)nO2CCH=CH2, Linear Formula: H2C=C(CH3)CO(OC3H6)nO2CC(CH3)=CH2. It is used in moisturizers and other skin care products as it helps reduce flakiness and restores suppleness of the skin. PPG, The most common antifreeze fluid - ethylene glycol - must not be used where there is a chance of leakage to potable water or food processing systems. Three-carbon deoxysugars are also precursor to the 1,2-diol. "Subchapter E - Animal Drugs, Feeds, and Related Products; § 582.1666. Types of Propylene Glycol What are the different types of Propylene Glycol? Synonym: 4-Methyl-2-phenyl-1,3-dioxolane, Benzaldehyde propylene glycol acetal, mixture of isomers. Exposures to propylene glycol having no adverse effects on the mother should have no effect on the fetus. Dipropylene glycol monomethyl ether, Empirical Formula (Hill Notation): C16H24O3, 9 Use of USP (US Pharmacopoeia) propylene glycol can reduce the risk of Abbreviated New Drug Application (ANDA) rejection.[7]. Adverse effects to intravenous administration of drugs that use propylene glycol as an excipient have been seen in a number of people, particularly with large bolus dosages. This material and its container must be disposed of in a safe way. Chest 2005;128(3):1674-81. Density varies with temperature and the graphs below show the densities of Dow’s glycols and glycol-water solutions over a … In the pharmaceutical world, propylene glycol makes topical, intravenous and oral medications more soluble. [69] Propylene glycol is readily biodegradable under aerobic conditions in freshwater, in seawater and in soil. Page: 4/6. Title 21, U.S. Code of Federal Regulations. Propylene glycol toxicity: a severe iatrogenic illness in ICU patients receiving IV benzodiazepines: a case series and prospective, observational pilot study. Forty-five percent of propylene glycol produced is used as a chemical feedstock for the production of unsaturated polyester resins. 1,2-Propanediol monomethyl ether acetate, Propylene glycol is chiral. Food makers value it for its ability to keep a substance moist, maintain texture, and mix with almost anything (oil, alcohol, and water). 1991. An unsaturated polyester, made from propylene glycol and fumaric acid, is suitable as resorbable bone cement. Contact Propylene glycol occurs naturally, probably as the result of anaerobic catabolism of sugars in the human gut. 1,2-Diacetoxypropane, /LABORATORY ANIMALS: Acute Exposure/ Propylene glycol was relatively harmless (LD50 = 21 g/kg) in acute oral toxicity studies involving rats. Propylene glycol is a synthetic food additive that belongs to the same chemical group as alcohol. The compound is sometimes called (alpha) α-propylene glycol to distinguish it from the isomer propane-1,3-diol, known as (beta) β-propylene glycol. Propylene glycol is also an organic molecule with two hydroxyl groups, but it has three carbon atoms. Propylene Glycol Biological Activity Description (±)-1,2-Propanediol is an aliphatic alcohol and frequently used as an excipient in many drug formulations to increase the solubility and stability of drugs. [4], A small-scale, nonbiological route from D-mannitol is illustrated in the following scheme:[8]. Therefore, propylene glycol allergy is more common in those countries.[64]. Here is a breakdown of each one: Propylene Glycol - 99.9% Pure internally repackaged certified USP grade that is packaged in containers starting at 2 oz to 5 Gallons. WHO, 1995. Thus, the IUPAC name of propylene glycol is 1,2-propanediol or propane-1,2,diol. [30] Propylene glycol is metabolized in the human body into pyruvic acid (a normal part of the glucose-metabolism process, readily converted to energy), acetic acid (handled by ethanol-metabolism), lactic acid (a normal acid generally abundant during digestion),[31] and propionaldehyde (a potentially hazardous substance). Propylene glycol is also used to make polyester compounds, and as a base for deicing solutions. Propylene glycol is a synthetic liquid substance that absorbs water. Acute oral toxicity studies on polypropylene glycols of various molecular weights (300 to 3900 Da) have indicated LD50 values (rats) ranging from 0.5 to >40g/kg. Propylene glycol, 7 PubMed; Horinek EL et al. Propylene glycol is a compound which is GRAS (generally recognized as safe) by the US FDA (Food and Drug Administration) under 21 CFR x184.1666, and is also approved by the FDA for certain uses as an indirect food additive. Propylene Glycols - Density Values Question What are the density values for glycols and glycol-water solutions? It serves as both the carrier for substances like nicotine and cannabinoids, as well as for creating a vapor which resembles smoke.[19]. [9][10] Vaporizers used for delivery of pharmaceuticals or personal-care products often include propylene glycol among the ingredients. It is used as aircraft de-icing fluid. Propylene glycol accumulation in critically ill patients receiving continuous intravenous lorazepam infusions. [38] Cases of propylene glycol poisoning are usually related to either inappropriate intravenous administration or accidental ingestion of large quantities by children. Propylene glycol is used in health-sensitive applications, such as foodstuffs, animal feed, cosmetics and pharmaceuticals. Reproduction of any materials from the site is strictly forbidden without permission. [54] A high percentage (12% to 42%) of directly-injected propylene glycol is eliminated or secreted in urine unaltered depending on dosage, with the remainder appearing in its glucuronide-form. [4][14] Water-propylene glycol mixtures dyed pink to indicate the mixture is relatively nontoxic are sold under the name of RV or marine antifreeze. Product Results, |  Match Criteria: Product Name, Property, Description, Synonym: Propylene glycol methyl ether acetate, .alpha.-isomer / PGMEA / 1-Methoxypropan-2-yl acetate / Acetic acid, 2-methoxyisopropyl ester / 1-Methoxypropan-2-ol acetate 1.2. 4-Methyl-2-phenyl-1,3-dioxolane, Dihydroxyacetone phosphate, one of the two products of breakdown (glycolysis) of fructose 1,6-bisphosphate, is a precursor to methylglyoxal. Empirical Formula (Hill Notation): C10H12O2. Propylene glycol is also present in propylene glycol alginate, which is known as E405. [12] PG is also used as a solvent and carrier for many pharmaceutical capsule preparations. Product Result, Synonym: Propylene glycol methyl ether acetate, 2 Propylene diacetate, Synonym: https://en.wikipedia.org/w/index.php?title=Propylene_glycol&oldid=996339556, Chemical articles with multiple compound IDs, Multiple chemicals in an infobox that need indexing, Chemical articles with multiple CAS registry numbers, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Creative Commons Attribution-ShareAlike License, In veterinary medicine as an oral treatment for. [42], Propylene glycol is essentially non-irritating to the skin. This conversion is the basis of a potential biotechnological route to the commodity chemical 1,2-propanediol. National Library of Medicine;.Propylene glycol is used in antifreezes Human Toxicity Excerpts: CAS Registry Number: 57-55-6 (1,2-Propylene Glycol). matches found for Propylene glycol (IUPAC name: propane-1,2-diol) is a viscous, colorless liquid, which is nearly odorless but possesses a faintly sweet taste. 2005. Always drain and flush systems containing propylene glycol with water before welding or other maintenance. Pricing & availability is not currently available. In this regard, propylene glycol reacts with a mixture of unsaturated maleic anhydride and isophthalic acid to give a copolymer. [56] In one case, intravenous administration of propylene glycol-suspended nitroglycerin to an elderly man may have induced coma and acidosis. [60] Heinz body formation from MPG has not been observed in dogs, cattle, or humans. Propylene glycol, also known as 1,2-propanediol, is a synthetic (i.e., man-made) alcohol that attracts/absorbs water. [39], The potential for long-term oral toxicity is also low. It is a clear, colorelss, viscous liquid, slightly bitter-tasting. *Please select more than one item to compare, 211 Propylene glycol is used by the chemical, food, and pharmaceutical industries as an antifreeze when leakage might lead to contact with food. [26] The safety of electronic cigarettes—which utilize PG-based preparations of nicotine or THC and other cannabinoids—is the subject of much controversy. CAS Number: 2568-25-4. Propylene glycol methyl ether ( PGME or 1-methoxy-2-propanol) is an organic solvent with a wide variety of industrial and commercial uses. "Subchapter B - Food for Human Consumption. Empty containers or liners may retain some product residues. Due to its low toxicity, propylene glycol can be purchased from certain food stores and chemical suppliers, in various grades. In general, glycols are non-irritating and have very low volatility.[4]. Beilstein/REAXYS Number: 1340498. Responses may include CNS depression, "hypotension, bradycardia, QRS and T abnormalities on the ECG, arrhythmia, cardiac arrhythmias, seizures, agitation, serum hyperosmolality, lactic acidosis, and haemolysis". Propylene glycol skin sensitization occurred in patients sensitive to a number of other concomitant positive allergens, most common of which were: Myroxylon pereirae resin, benzalkonium chloride, carba mix, potassium dichromate, neomycin sulfate; for positive propylene glycol reactions, the overall median of 5 and mean of 5.6 concomitant positive allergens was reported. [16][17] The −50 °F/−45 °C commercial product is, however, water rich; a typical formulation is 40:60. [6] Further purification produces finished industrial grade or USP/JP/EP/BP grade propylene glycol that is typically 99.5% or greater. Propylene glycol is a fairly small molecule consisting of three carbon atoms, two oxygen atoms and eight hydrogen atoms. Molecular Weight: 76.09. Because of its potential for allergic reactions and frequent use across a variety of topical and systemic products, propylene glycol was named the American Contact Dermatitis Society's Allergen of the Year for 2018. [43] Undiluted propylene glycol is minimally irritating to the eye, producing slight transient conjunctivitis; the eye recovers after the exposure is removed. The potential hazards of chronic inhalation of propylene glycol or the latter substance as a whole are as-yet unknown. Propylene glycol (IUPAC name: propane-1,2-diol) is a viscous, colorless liquid, which is nearly odorless but possesses a faintly sweet taste. The positive reaction rates were 0%, 0.26%, and 1.86% for 5%, 10%, and 20% propylene glycol respectively, increasing with each concentration increase. Answer Density is the weight per unit volume of a mass. [48][49][50], Propylene glycol has not caused sensitization or carcinogenicity in laboratory animal studies, nor has it demonstrated genotoxic potential.[51][52]. Propylene glycol is frequently used as a substitute for ethylene glycol in low toxicity, environmentally friendly automotive antifreeze. It is miscible with a broad range of solvents, including water, acetone, and chloroform. [15] The eutectic composition/temperature is 60:40 propylene glycol:water/-60 °C. The International Programme on Chemical Safety: Basic Analytical Toxicology. When used in a lotion or ointment, propylene glycol increases the skin’s ability to absorb whatever it’s applied to it, which could help medications work better. Dispose of surplus and non-recyclable products via a In the cosmetics industry, where PG is very commonly used as a carrier or base for various types of makeup. PGMEA, 1,2-Propanediol diacetate, [53] Ruddick (1972) also summarized intramuscular LD50 data for rat as 13-20 mL/kg BW, and 6 mL/kg BW for the rabbit. Related to this application, propylene glycol reacts with propylene oxide to give oligomers and polymers that are used to produce polyurethanes. [4] In alcohol-based hand sanitizers, it is used as a humectant to prevent the skin from drying. Propylene glycol is one of the most widely used cosmetic ingredients, as it is a humectant. Propylene glycol Version 1.2 Revision Date: 10/30/2014 MSDS Number: 100000008803 5 / 16 Propylene glycol Water solubility : completely soluble @ 20 °C (68 °F) Solubility in other sol-vents : No data available Partition coefficient: n-octanol/water : log Pow: -1.07 Auto-ignition temperature : … Wilson KC et al. ", "Material Safety Data Sheet: Winter Care RV Antifreeze", "Predicting Abraham model solvent coefficients", "Atmosphere: Hazers, Fazers, Smoke and Fog 101 by Daniel Brea", "Material Safety Data Sheet Propionaldehyde MSDS", "Database of Select Committee on GRAS Substances (SCOGS) Reviews", "Tests for the chronic toxicity of propylene glycol and triethylene glycol on monkeys and rats by vapor inhalation and oral administration", https://vapingcheap.com/vaping-vs-smoking/#tab-con-1, "Everyday Substances Increase Risk of Allergies in Children, Swedish Study Reveals", "Chemical Compounds Emitted From Common Household Paints and Cleaners Increase Risks of Asthma and Allergies in Children", "Common Household Chemicals and the Allergy Risks in Pre-School Age Children", http://www.inchem.org/documents/pims/chemical/pim443.htm#SectionTitle:9.1%20%20Acute%20poisoning, "Allergen of the year may be nearer than you think", ATSDR - Case Studies in Environmental Medicine: Ethylene Glycol and Propylene Glycol Toxicity. 4-Methyl-2-phenyl-1,3-dioxolane, Synonym: [67] 87% of the reactions were classified as weak and 9% as strong. The LD50 is higher for most laboratory animals (20 mL/kg). Estimated levels of exposure to propylene glycol and glycerine are close enough to [workplace limits] to warrant concern. 57-55-6 1.3 Recommended use of the chemical and restrictions on use Skin Cosmetics 1.4 Supplier's details Name Bulk Apothecary Address 115 Lena Dr Aurora OH 44202 United States Propylene glycol is used by the chemical, food, and pharmaceutical industries as an antifreeze when leakage might lead to Poly(propylene oxide), 4 [4] Propylene glycol is used in waterbased acrylic architectural paints to extend dry time which it accomplishes by preventing the surface from drying due to its slower evaporation rate compared to water. Customer Service. Commercial processes typically use the racemate. Propylene glycol -1 - low 2/10/2010. Product Results, Synonym: [18], Along with vegetable glycerin as the main ingredient (<1–92%) in e-liquid used in electronic cigarettes, where it is aerosolized to resemble smoke. [40] Because of its low chronic oral toxicity, propylene glycol was classified by the U. S. Food and Drug Administration as "generally recognized as safe" (GRAS) for use as a direct food additive, including frozen foods such as ice cream and frozen desserts. It is a colorless, odorless, slightly syrupy liquid that is a bit thicker than water. It also finds use as an industrial and commercial paint stripper. 1,2-Propanediol monomethyl ether acetate, Benzaldehyde propylene glycol acetal, mixture of isomers, Pharmaceutical Secondary Standard; Certified Reference Material, United States Pharmacopeia (USP) Reference Standard, European Pharmacopoeia (EP) Reference Standard, British Pharmacopoeia (BP) Reference Standard. Site Use Terms It is a viscous, colorless liquid, which is … Propylene glycol is a synthetic liquid substance that absorbs water. Propylene glycol is approved and used as a vehicle for topical, oral, and some intravenous pharmaceutical preparations in the U.S. and in Europe. Biopharmaceutical Process Development and Manufacturing, Decanoic acid, mixed diesters with octanoic acid and propylene glycol, Dodecanoic acid, ester with 1,2-propanediol. There are four different propylene glycol. Sorry we cannot compare more than 4 products at a time. CAS Number: 57-55-6. Propylene Glycol USP is the most common moisture-carrying vehicle, other than water itself, in cosmetics. | Privacy. Propylene glycol is an ingredient that acts as a humectant for hair. [11] Propylene glycol is used as a solvent in many pharmaceuticals, including oral, injectable, and topical formulations. [5], Final products contain 20% propylene glycol, 1.5% of dipropylene glycol, and small amounts of other polypropylene glycols. 1999. Although these are great benefits for the hair, some people experience an allergic reaction to propylene glycol on their scalps.

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